The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Identifieur interne : 001541 ( Main/Exploration ); précédent : 001540; suivant : 001542The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Auteurs : Paul M. Scola [États-Unis] ; Li-Qiang Sun ; Alan Xiangdong Wang ; Jie Chen ; Ny Sin ; Brian L. Venables ; Sing-Yuen Sit ; Yan Chen ; Anthony Cocuzza ; Donna M. Bilder ; Stanley V. D'Andrea ; Barbara Zheng ; Piyasena Hewawasam ; Yong Tu ; Jacques Friborg ; Paul Falk ; Dennis Hernandez ; Steven Levine ; Chaoqun Chen ; Fei Yu ; Amy K. Sheaffer ; Guangzhi Zhai ; Diana Barry ; Jay O. Knipe ; Yong-Hae Han ; Richard Schartman ; Maria Donoso ; Kathy Mosure ; Michael W. Sinz ; Tatyana Zvyaga ; Andrew C. Good ; Ramkumar Rajamani ; Kevin Kish ; Jeffrey Tredup ; Herbert E. Klei ; Qi Gao ; Luciano Mueller ; Richard J. Colonno ; Dennis M. Grasela ; Stephen P. Adams ; James Loy ; Paul C. Levesque ; Huabin Sun ; Hong Shi ; Lucy Sun ; William Warner ; Danshi Li ; Jialong Zhu ; Nicholas A. Meanwell ; Fiona McpheeSource :
- Journal of medicinal chemistry [ 1520-4804 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (sang), Antiviraux (usage thérapeutique), Chiens, Humains, Hépatite C (traitement médicamenteux), Inhibiteurs de protéases (), Inhibiteurs de protéases (sang), Inhibiteurs de protéases (usage thérapeutique), Isoquinoléines (), Isoquinoléines (sang), Isoquinoléines (usage thérapeutique), Lapins, Modèles moléculaires, Protéines virales non structurales (antagonistes et inhibiteurs), Rats, Sulfonamides (), Sulfonamides (sang), Sulfonamides (usage thérapeutique).
- MESH :
- antagonistes et inhibiteurs : Protéines virales non structurales.
- sang : Antiviraux, Inhibiteurs de protéases, Isoquinoléines, Sulfonamides.
- traitement médicamenteux : Hépatite C.
- usage thérapeutique : Antiviraux, Inhibiteurs de protéases, Isoquinoléines, Sulfonamides.
- Animaux, Antiviraux, Chiens, Humains, Inhibiteurs de protéases, Isoquinoléines, Lapins, Modèles moléculaires, Rats, Sulfonamides.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (blood), Antiviral Agents (chemistry), Antiviral Agents (therapeutic use), Dogs, Hepatitis C (drug therapy), Humans, Isoquinolines (blood), Isoquinolines (chemistry), Isoquinolines (therapeutic use), Models, Molecular, Protease Inhibitors (blood), Protease Inhibitors (chemistry), Protease Inhibitors (therapeutic use), Rabbits, Rats, Sulfonamides (blood), Sulfonamides (chemistry), Sulfonamides (therapeutic use), Viral Nonstructural Proteins (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Viral Nonstructural Proteins.
- chemical , blood : Antiviral Agents, Isoquinolines, Protease Inhibitors, Sulfonamides.
- chemical , chemistry : Antiviral Agents, Isoquinolines, Protease Inhibitors, Sulfonamides.
- chemical , therapeutic use : Antiviral Agents, Isoquinolines, Protease Inhibitors, Sulfonamides.
- drug therapy : Hepatitis C.
- Animals, Dogs, Humans, Models, Molecular, Rabbits, Rats.
Abstract
The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis C virus infection. The discovery of 24 was enabled by employing an isolated rabbit heart model to screen for the cardiovascular (CV) liabilities (changes to HR and SNRT) that were responsible for the discontinuation of an earlier lead from this chemical series, BMS-605339 (1), from clinical trials. The structure-activity relationships (SARs) developed with respect to CV effects established that small structural changes to the P2* subsite of the molecule had a significant impact on the CV profile of a given compound. The antiviral activity, preclincial PK profile, and toxicology studies in rat and dog supported clinical development of BMS-650032 (24).
DOI: 10.1021/jm500297k
PubMed: 24564672
Affiliations:
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Scola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development , 5 Research Parkway, Wallingford, Connecticut, 06492, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development , 5 Research Parkway, Wallingford, Connecticut, 06492</wicri:regionArea><wicri:noRegion>06492</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Li Qiang" sort="Sun, Li Qiang" uniqKey="Sun L" first="Li-Qiang" last="Sun">Li-Qiang Sun</name></author><author><name sortKey="Wang, Alan Xiangdong" sort="Wang, Alan Xiangdong" uniqKey="Wang A" first="Alan Xiangdong" last="Wang">Alan Xiangdong Wang</name></author><author><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name></author><author><name sortKey="Sin, Ny" sort="Sin, Ny" uniqKey="Sin N" first="Ny" last="Sin">Ny Sin</name></author><author><name sortKey="Venables, Brian L" sort="Venables, Brian L" uniqKey="Venables B" first="Brian L" last="Venables">Brian L. Venables</name></author><author><name sortKey="Sit, Sing Yuen" sort="Sit, Sing Yuen" uniqKey="Sit S" first="Sing-Yuen" last="Sit">Sing-Yuen Sit</name></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name></author><author><name sortKey="Cocuzza, Anthony" sort="Cocuzza, Anthony" uniqKey="Cocuzza A" first="Anthony" last="Cocuzza">Anthony Cocuzza</name></author><author><name sortKey="Bilder, Donna M" sort="Bilder, Donna M" uniqKey="Bilder D" first="Donna M" last="Bilder">Donna M. Bilder</name></author><author><name sortKey="D Andrea, Stanley V" sort="D Andrea, Stanley V" uniqKey="D Andrea S" first="Stanley V" last="D'Andrea">Stanley V. D'Andrea</name></author><author><name sortKey="Zheng, Barbara" sort="Zheng, Barbara" uniqKey="Zheng B" first="Barbara" last="Zheng">Barbara Zheng</name></author><author><name sortKey="Hewawasam, Piyasena" sort="Hewawasam, Piyasena" uniqKey="Hewawasam P" first="Piyasena" last="Hewawasam">Piyasena Hewawasam</name></author><author><name sortKey="Tu, Yong" sort="Tu, Yong" uniqKey="Tu Y" first="Yong" last="Tu">Yong Tu</name></author><author><name sortKey="Friborg, Jacques" sort="Friborg, Jacques" uniqKey="Friborg J" first="Jacques" last="Friborg">Jacques Friborg</name></author><author><name sortKey="Falk, Paul" sort="Falk, Paul" uniqKey="Falk P" first="Paul" last="Falk">Paul Falk</name></author><author><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name></author><author><name sortKey="Levine, Steven" sort="Levine, Steven" uniqKey="Levine S" first="Steven" last="Levine">Steven Levine</name></author><author><name sortKey="Chen, Chaoqun" sort="Chen, Chaoqun" uniqKey="Chen C" first="Chaoqun" last="Chen">Chaoqun Chen</name></author><author><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name></author><author><name sortKey="Sheaffer, Amy K" sort="Sheaffer, Amy K" uniqKey="Sheaffer A" first="Amy K" last="Sheaffer">Amy K. Sheaffer</name></author><author><name sortKey="Zhai, Guangzhi" sort="Zhai, Guangzhi" uniqKey="Zhai G" first="Guangzhi" last="Zhai">Guangzhi Zhai</name></author><author><name sortKey="Barry, Diana" sort="Barry, Diana" uniqKey="Barry D" first="Diana" last="Barry">Diana Barry</name></author><author><name sortKey="Knipe, Jay O" sort="Knipe, Jay O" uniqKey="Knipe J" first="Jay O" last="Knipe">Jay O. Knipe</name></author><author><name sortKey="Han, Yong Hae" sort="Han, Yong Hae" uniqKey="Han Y" first="Yong-Hae" last="Han">Yong-Hae Han</name></author><author><name sortKey="Schartman, Richard" sort="Schartman, Richard" uniqKey="Schartman R" first="Richard" last="Schartman">Richard Schartman</name></author><author><name sortKey="Donoso, Maria" sort="Donoso, Maria" uniqKey="Donoso M" first="Maria" last="Donoso">Maria Donoso</name></author><author><name sortKey="Mosure, Kathy" sort="Mosure, Kathy" uniqKey="Mosure K" first="Kathy" last="Mosure">Kathy Mosure</name></author><author><name sortKey="Sinz, Michael W" sort="Sinz, Michael W" uniqKey="Sinz M" first="Michael W" last="Sinz">Michael W. Sinz</name></author><author><name sortKey="Zvyaga, Tatyana" sort="Zvyaga, Tatyana" uniqKey="Zvyaga T" first="Tatyana" last="Zvyaga">Tatyana Zvyaga</name></author><author><name sortKey="Good, Andrew C" sort="Good, Andrew C" uniqKey="Good A" first="Andrew C" last="Good">Andrew C. Good</name></author><author><name sortKey="Rajamani, Ramkumar" sort="Rajamani, Ramkumar" uniqKey="Rajamani R" first="Ramkumar" last="Rajamani">Ramkumar Rajamani</name></author><author><name sortKey="Kish, Kevin" sort="Kish, Kevin" uniqKey="Kish K" first="Kevin" last="Kish">Kevin Kish</name></author><author><name sortKey="Tredup, Jeffrey" sort="Tredup, Jeffrey" uniqKey="Tredup J" first="Jeffrey" last="Tredup">Jeffrey Tredup</name></author><author><name sortKey="Klei, Herbert E" sort="Klei, Herbert E" uniqKey="Klei H" first="Herbert E" last="Klei">Herbert E. Klei</name></author><author><name sortKey="Gao, Qi" sort="Gao, Qi" uniqKey="Gao Q" first="Qi" last="Gao">Qi Gao</name></author><author><name sortKey="Mueller, Luciano" sort="Mueller, Luciano" uniqKey="Mueller L" first="Luciano" last="Mueller">Luciano Mueller</name></author><author><name sortKey="Colonno, Richard J" sort="Colonno, Richard J" uniqKey="Colonno R" first="Richard J" last="Colonno">Richard J. Colonno</name></author><author><name sortKey="Grasela, Dennis M" sort="Grasela, Dennis M" uniqKey="Grasela D" first="Dennis M" last="Grasela">Dennis M. Grasela</name></author><author><name sortKey="Adams, Stephen P" sort="Adams, Stephen P" uniqKey="Adams S" first="Stephen P" last="Adams">Stephen P. Adams</name></author><author><name sortKey="Loy, James" sort="Loy, James" uniqKey="Loy J" first="James" last="Loy">James Loy</name></author><author><name sortKey="Levesque, Paul C" sort="Levesque, Paul C" uniqKey="Levesque P" first="Paul C" last="Levesque">Paul C. Levesque</name></author><author><name sortKey="Sun, Huabin" sort="Sun, Huabin" uniqKey="Sun H" first="Huabin" last="Sun">Huabin Sun</name></author><author><name sortKey="Shi, Hong" sort="Shi, Hong" uniqKey="Shi H" first="Hong" last="Shi">Hong Shi</name></author><author><name sortKey="Sun, Lucy" sort="Sun, Lucy" uniqKey="Sun L" first="Lucy" last="Sun">Lucy Sun</name></author><author><name sortKey="Warner, William" sort="Warner, William" uniqKey="Warner W" first="William" last="Warner">William Warner</name></author><author><name sortKey="Li, Danshi" sort="Li, Danshi" uniqKey="Li D" first="Danshi" last="Li">Danshi Li</name></author><author><name sortKey="Zhu, Jialong" sort="Zhu, Jialong" uniqKey="Zhu J" first="Jialong" last="Zhu">Jialong Zhu</name></author><author><name sortKey="Meanwell, Nicholas A" sort="Meanwell, Nicholas A" uniqKey="Meanwell N" first="Nicholas A" last="Meanwell">Nicholas A. Meanwell</name></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name></author></analytic><series><title level="j">Journal of medicinal chemistry</title><idno type="eISSN">1520-4804</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (blood)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (therapeutic use)</term><term>Dogs</term><term>Hepatitis C (drug therapy)</term><term>Humans</term><term>Isoquinolines (blood)</term><term>Isoquinolines (chemistry)</term><term>Isoquinolines (therapeutic use)</term><term>Models, Molecular</term><term>Protease Inhibitors (blood)</term><term>Protease Inhibitors (chemistry)</term><term>Protease Inhibitors (therapeutic use)</term><term>Rabbits</term><term>Rats</term><term>Sulfonamides (blood)</term><term>Sulfonamides (chemistry)</term><term>Sulfonamides (therapeutic use)</term><term>Viral Nonstructural Proteins (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (sang)</term><term>Antiviraux (usage thérapeutique)</term><term>Chiens</term><term>Humains</term><term>Hépatite C (traitement médicamenteux)</term><term>Inhibiteurs de protéases ()</term><term>Inhibiteurs de protéases (sang)</term><term>Inhibiteurs de protéases (usage thérapeutique)</term><term>Isoquinoléines ()</term><term>Isoquinoléines (sang)</term><term>Isoquinoléines (usage thérapeutique)</term><term>Lapins</term><term>Modèles moléculaires</term><term>Protéines virales non structurales (antagonistes et inhibiteurs)</term><term>Rats</term><term>Sulfonamides ()</term><term>Sulfonamides (sang)</term><term>Sulfonamides (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antiviral Agents</term><term>Isoquinolines</term><term>Protease Inhibitors</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Isoquinolines</term><term>Protease Inhibitors</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Isoquinolines</term><term>Protease Inhibitors</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antiviraux</term><term>Inhibiteurs de protéases</term><term>Isoquinoléines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Inhibiteurs de protéases</term><term>Isoquinoléines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Humans</term><term>Models, Molecular</term><term>Rabbits</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Chiens</term><term>Humains</term><term>Inhibiteurs de protéases</term><term>Isoquinoléines</term><term>Lapins</term><term>Modèles moléculaires</term><term>Rats</term><term>Sulfonamides</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis C virus infection. The discovery of 24 was enabled by employing an isolated rabbit heart model to screen for the cardiovascular (CV) liabilities (changes to HR and SNRT) that were responsible for the discontinuation of an earlier lead from this chemical series, BMS-605339 (1), from clinical trials. The structure-activity relationships (SARs) developed with respect to CV effects established that small structural changes to the P2* subsite of the molecule had a significant impact on the CV profile of a given compound. The antiviral activity, preclincial PK profile, and toxicology studies in rat and dog supported clinical development of BMS-650032 (24). </div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Adams, Stephen P" sort="Adams, Stephen P" uniqKey="Adams S" first="Stephen P" last="Adams">Stephen P. Adams</name><name sortKey="Barry, Diana" sort="Barry, Diana" uniqKey="Barry D" first="Diana" last="Barry">Diana Barry</name><name sortKey="Bilder, Donna M" sort="Bilder, Donna M" uniqKey="Bilder D" first="Donna M" last="Bilder">Donna M. Bilder</name><name sortKey="Chen, Chaoqun" sort="Chen, Chaoqun" uniqKey="Chen C" first="Chaoqun" last="Chen">Chaoqun Chen</name><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Cocuzza, Anthony" sort="Cocuzza, Anthony" uniqKey="Cocuzza A" first="Anthony" last="Cocuzza">Anthony Cocuzza</name><name sortKey="Colonno, Richard J" sort="Colonno, Richard J" uniqKey="Colonno R" first="Richard J" last="Colonno">Richard J. Colonno</name><name sortKey="D Andrea, Stanley V" sort="D Andrea, Stanley V" uniqKey="D Andrea S" first="Stanley V" last="D'Andrea">Stanley V. D'Andrea</name><name sortKey="Donoso, Maria" sort="Donoso, Maria" uniqKey="Donoso M" first="Maria" last="Donoso">Maria Donoso</name><name sortKey="Falk, Paul" sort="Falk, Paul" uniqKey="Falk P" first="Paul" last="Falk">Paul Falk</name><name sortKey="Friborg, Jacques" sort="Friborg, Jacques" uniqKey="Friborg J" first="Jacques" last="Friborg">Jacques Friborg</name><name sortKey="Gao, Qi" sort="Gao, Qi" uniqKey="Gao Q" first="Qi" last="Gao">Qi Gao</name><name sortKey="Good, Andrew C" sort="Good, Andrew C" uniqKey="Good A" first="Andrew C" last="Good">Andrew C. Good</name><name sortKey="Grasela, Dennis M" sort="Grasela, Dennis M" uniqKey="Grasela D" first="Dennis M" last="Grasela">Dennis M. Grasela</name><name sortKey="Han, Yong Hae" sort="Han, Yong Hae" uniqKey="Han Y" first="Yong-Hae" last="Han">Yong-Hae Han</name><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name><name sortKey="Hewawasam, Piyasena" sort="Hewawasam, Piyasena" uniqKey="Hewawasam P" first="Piyasena" last="Hewawasam">Piyasena Hewawasam</name><name sortKey="Kish, Kevin" sort="Kish, Kevin" uniqKey="Kish K" first="Kevin" last="Kish">Kevin Kish</name><name sortKey="Klei, Herbert E" sort="Klei, Herbert E" uniqKey="Klei H" first="Herbert E" last="Klei">Herbert E. Klei</name><name sortKey="Knipe, Jay O" sort="Knipe, Jay O" uniqKey="Knipe J" first="Jay O" last="Knipe">Jay O. Knipe</name><name sortKey="Levesque, Paul C" sort="Levesque, Paul C" uniqKey="Levesque P" first="Paul C" last="Levesque">Paul C. Levesque</name><name sortKey="Levine, Steven" sort="Levine, Steven" uniqKey="Levine S" first="Steven" last="Levine">Steven Levine</name><name sortKey="Li, Danshi" sort="Li, Danshi" uniqKey="Li D" first="Danshi" last="Li">Danshi Li</name><name sortKey="Loy, James" sort="Loy, James" uniqKey="Loy J" first="James" last="Loy">James Loy</name><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><name sortKey="Meanwell, Nicholas A" sort="Meanwell, Nicholas A" uniqKey="Meanwell N" first="Nicholas A" last="Meanwell">Nicholas A. Meanwell</name><name sortKey="Mosure, Kathy" sort="Mosure, Kathy" uniqKey="Mosure K" first="Kathy" last="Mosure">Kathy Mosure</name><name sortKey="Mueller, Luciano" sort="Mueller, Luciano" uniqKey="Mueller L" first="Luciano" last="Mueller">Luciano Mueller</name><name sortKey="Rajamani, Ramkumar" sort="Rajamani, Ramkumar" uniqKey="Rajamani R" first="Ramkumar" last="Rajamani">Ramkumar Rajamani</name><name sortKey="Schartman, Richard" sort="Schartman, Richard" uniqKey="Schartman R" first="Richard" last="Schartman">Richard Schartman</name><name sortKey="Sheaffer, Amy K" sort="Sheaffer, Amy K" uniqKey="Sheaffer A" first="Amy K" last="Sheaffer">Amy K. Sheaffer</name><name sortKey="Shi, Hong" sort="Shi, Hong" uniqKey="Shi H" first="Hong" last="Shi">Hong Shi</name><name sortKey="Sin, Ny" sort="Sin, Ny" uniqKey="Sin N" first="Ny" last="Sin">Ny Sin</name><name sortKey="Sinz, Michael W" sort="Sinz, Michael W" uniqKey="Sinz M" first="Michael W" last="Sinz">Michael W. Sinz</name><name sortKey="Sit, Sing Yuen" sort="Sit, Sing Yuen" uniqKey="Sit S" first="Sing-Yuen" last="Sit">Sing-Yuen Sit</name><name sortKey="Sun, Huabin" sort="Sun, Huabin" uniqKey="Sun H" first="Huabin" last="Sun">Huabin Sun</name><name sortKey="Sun, Li Qiang" sort="Sun, Li Qiang" uniqKey="Sun L" first="Li-Qiang" last="Sun">Li-Qiang Sun</name><name sortKey="Sun, Lucy" sort="Sun, Lucy" uniqKey="Sun L" first="Lucy" last="Sun">Lucy Sun</name><name sortKey="Tredup, Jeffrey" sort="Tredup, Jeffrey" uniqKey="Tredup J" first="Jeffrey" last="Tredup">Jeffrey Tredup</name><name sortKey="Tu, Yong" sort="Tu, Yong" uniqKey="Tu Y" first="Yong" last="Tu">Yong Tu</name><name sortKey="Venables, Brian L" sort="Venables, Brian L" uniqKey="Venables B" first="Brian L" last="Venables">Brian L. Venables</name><name sortKey="Wang, Alan Xiangdong" sort="Wang, Alan Xiangdong" uniqKey="Wang A" first="Alan Xiangdong" last="Wang">Alan Xiangdong Wang</name><name sortKey="Warner, William" sort="Warner, William" uniqKey="Warner W" first="William" last="Warner">William Warner</name><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><name sortKey="Zhai, Guangzhi" sort="Zhai, Guangzhi" uniqKey="Zhai G" first="Guangzhi" last="Zhai">Guangzhi Zhai</name><name sortKey="Zheng, Barbara" sort="Zheng, Barbara" uniqKey="Zheng B" first="Barbara" last="Zheng">Barbara Zheng</name><name sortKey="Zhu, Jialong" sort="Zhu, Jialong" uniqKey="Zhu J" first="Jialong" last="Zhu">Jialong Zhu</name><name sortKey="Zvyaga, Tatyana" sort="Zvyaga, Tatyana" uniqKey="Zvyaga T" first="Tatyana" last="Zvyaga">Tatyana Zvyaga</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Scola, Paul M" sort="Scola, Paul M" uniqKey="Scola P" first="Paul M" last="Scola">Paul M. Scola</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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